Influenza-specific antibody-secreting cells and B cell memory in the murine lung after immunization with wild-type, cold-adapted variant and inactivated influenza viruses
Identifieur interne : 002300 ( Main/Exploration ); précédent : 002299; suivant : 002301Influenza-specific antibody-secreting cells and B cell memory in the murine lung after immunization with wild-type, cold-adapted variant and inactivated influenza viruses
Auteurs : P. D. Jones [Australie] ; G. L. Ada [Australie]Source :
- Vaccine [ 0264-410X ] ; 1987.
English descriptors
- Teeft :
- Ascs, Assay, Cavariant virus, Cell memory, Cell responses, Dos, Eidso, Immunization, Influenza, Influenza vaccines, Inoculation, Inoculum, Intranasally, Lung cell cultures, Lung virus titres, Memory cells, Murine, Murine lung, Murine studies, Parental, Parental strain, Parental strains, Parental virus, Primary immunization, Primary inoculation, Primary response, Single inoculum, Spleen, Spleen cell cultures, Splenic, Splenic responses, Titre, Tracheobronchial washings, Unprimed, Unprimed mice, Vaccine, Virus.
Abstract
Abstract: The development of regional B cell responses was studied in mice immunized intranasally with different influenza virus vaccines. The ca-variant virus was 100-fold less efficient than the parental virus in the induction of influenza virus-specific antibody secreting cells (ASCs) in the lung and failed to induce ASCs in the spleen. The ca-variant virus was also less efficient in priming for secondary IgG and IgA responses generated in vitro in both lung and spleen cell cultures. Protection against homotypic challenge in mice immunized by different vaccine strategies correlated with the development of pulmonary B cell responses rather than splenic responses. In particular, protection correlated with the presence of ASCs and IgG and IgA memory in the lung at the time of challenge.
Url:
DOI: 10.1016/0264-410X(87)90109-5
Affiliations:
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Le document en format XML
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D." last="Jones">P. D. Jones</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, John Curtin School of Medical Research, Australian National University, P.O. Box 334 Canberra, A.C.T. 2601</wicri:regionArea><wicri:noRegion>A.C.T. 2601</wicri:noRegion></affiliation></author><author><name sortKey="Ada, G L" sort="Ada, G L" uniqKey="Ada G" first="G. L." last="Ada">G. L. Ada</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, John Curtin School of Medical Research, Australian National University, P.O. Box 334 Canberra, A.C.T. 2601</wicri:regionArea><wicri:noRegion>A.C.T. 2601</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Vaccine</title><title level="j" type="abbrev">JVAC</title><idno type="ISSN">0264-410X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1987">1987</date><biblScope unit="volume">5</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="244">244</biblScope><biblScope unit="page" to="248">248</biblScope></imprint><idno type="ISSN">0264-410X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Ascs</term><term>Assay</term><term>Cavariant virus</term><term>Cell memory</term><term>Cell responses</term><term>Dos</term><term>Eidso</term><term>Immunization</term><term>Influenza</term><term>Influenza vaccines</term><term>Inoculation</term><term>Inoculum</term><term>Intranasally</term><term>Lung cell cultures</term><term>Lung virus titres</term><term>Memory cells</term><term>Murine</term><term>Murine lung</term><term>Murine studies</term><term>Parental</term><term>Parental strain</term><term>Parental strains</term><term>Parental virus</term><term>Primary immunization</term><term>Primary inoculation</term><term>Primary response</term><term>Single inoculum</term><term>Spleen</term><term>Spleen cell cultures</term><term>Splenic</term><term>Splenic responses</term><term>Titre</term><term>Tracheobronchial washings</term><term>Unprimed</term><term>Unprimed mice</term><term>Vaccine</term><term>Virus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The development of regional B cell responses was studied in mice immunized intranasally with different influenza virus vaccines. The ca-variant virus was 100-fold less efficient than the parental virus in the induction of influenza virus-specific antibody secreting cells (ASCs) in the lung and failed to induce ASCs in the spleen. The ca-variant virus was also less efficient in priming for secondary IgG and IgA responses generated in vitro in both lung and spleen cell cultures. Protection against homotypic challenge in mice immunized by different vaccine strategies correlated with the development of pulmonary B cell responses rather than splenic responses. In particular, protection correlated with the presence of ASCs and IgG and IgA memory in the lung at the time of challenge.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Jones, P D" sort="Jones, P D" uniqKey="Jones P" first="P. D." last="Jones">P. D. Jones</name></noRegion><name sortKey="Ada, G L" sort="Ada, G L" uniqKey="Ada G" first="G. L." last="Ada">G. L. 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